{
  "id": "SCR-LIP-000290",
  "statement": "In a comparative observational study, 39.6% (21/53) of lipedema patients met ACR 2016 criteria for fibromyalgia, and the comorbid lipedema+fibromyalgia subgroup had significantly higher pain (median VAS 60 vs 27 for lipedema alone, p<0.001) and worse SF-36 quality-of-life scores across all 8 domains.",
  "statement_pt": "Em estudo observacional comparativo, 39,6% (21/53) das pacientes com lipedema preencheram os critérios ACR 2016 para fibromialgia, e o subgrupo comórbido lipedema+fibromialgia apresentou dor significativamente maior (VAS mediana 60 vs 27 no lipedema isolado, p<0,001) e piores escores de qualidade de vida pelo SF-36 em todos os 8 domínios.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.47582/jompac.1301253",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "moderate",
      "year": 2023,
      "amato_authored": false,
      "note": "The study directly quantifies the co-occurrence of fibromyalgia in lipedema patients (39.6% met ACR 2016 criteria) and characterizes pain/QoL effects, with results converging with prior studies (34%, 50%). It is observational and unadjusted"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000008",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000008"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000008",
      "role": "supporting",
      "question": "Is lipedema associated with fibromyalgia and other chronic-pain conditions?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000008.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000290.html"
}