{
  "id": "SCR-LIP-000351",
  "statement": "In a systematic review and meta-analysis of cross-sectional cohorts, women with lipedema showed reduced HRQoL across all SF-36/RAND-36 domains versus population norms, with the largest deficits in energy/fatigue (43.50 vs 59.4), bodily pain (51.77 vs 77.4), role physical (51.10 vs 82.4), and general health (49.64 vs 73.1), plus impaired emotional well-being (64.19 vs 73.2) reflecting frequent anxiety/depression.",
  "statement_pt": "Em uma revisão sistemática e meta-análise de coortes transversais, mulheres com lipedema apresentaram redução da QVRS em todos os domínios do SF-36/RAND-36 em comparação com valores normativos populacionais, com os maiores déficits em energia/fadiga (43,50 vs 59,4), dor corporal (51,77 vs 77,4), aspecto físico (51,10 vs 82,4) e saúde geral (49,64 vs 73,1), além de comprometimento do bem-estar emocional (64,19 vs 73,2) refletindo ansiedade/depressão frequentes.",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.1177/02683555251410009",
      "stance": "supporting",
      "study_design": "meta_analysis",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "moderate",
      "year": 2025,
      "amato_authored": false,
      "note": "Meta-analysis directly quantifying HRQoL and psychosocial impacts in lipedema patients with pooled effect sizes; high heterogeneity (I²=83–93%) lowers confidence."
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000020",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000020"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000020",
      "role": "supporting",
      "question": "How does lipedema affect quality of life, depression, and anxiety in affected patients?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000020.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000351.html"
}