{
  "id": "SCR-LIP-000356",
  "statement": "In a survey of lipedema patients, RAND-36 quality of life was significantly lower than the general Dutch female population (59.3 vs 74.9, p<0.001) and EQ-5D-3L was reduced (66.1 vs 85), with 42.0% reporting anxiety/depression and 74.1% reporting pain/discomfort (vs 31.1% in the general population).",
  "statement_pt": "Em um inquérito com pacientes com lipedema, a qualidade de vida pelo RAND-36 foi significativamente menor que a população feminina holandesa geral (59,3 vs 74,9, p<0,001) e o EQ-5D-3L foi reduzido (66,1 vs 85), com 42,0% relatando ansiedade/depressão e 74,1% relatando dor/desconforto (vs 31,1% na população geral).",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1007/s13555-018-0241-6",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2018,
      "amato_authored": false,
      "note": "Cross-sectional survey directly measuring QoL (RAND-36, EQ-5D-3L) and anxiety/depression in lipedema patients versus reference population, directly addressing the question."
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000020",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000020"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000020",
      "role": "supporting",
      "question": "How does lipedema affect quality of life, depression, and anxiety in affected patients?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000020.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000356.html"
}