{
  "id": "SCR-LIP-000357",
  "statement": "In a Swiss cohort of 239 lipedema patients assessed with validated questionnaires, 64.4% had anxiety (HADS≥8), 23.4% had depression (HADS≥8), and low quality of life was found in 71.5% (PCS-SF36) and 67.4% (MCS-SF36), with none of these psychosocial parameters differing significantly across disease stages (p>0.5).",
  "statement_pt": "Em uma coorte suíça de 239 pacientes com lipedema avaliados com questionários validados, 64,4% apresentaram ansiedade (HADS≥8), 23,4% depressão (HADS≥8), e baixa qualidade de vida foi encontrada em 71,5% (PCS-SF36) e 67,4% (MCS-SF36), sem diferença significativa desses parâmetros psicossociais entre os estágios da doença (p>0,5).",
  "claim_type": "clinical_association",
  "context": {
    "population": "—",
    "condition": "lipedema",
    "exposure": "—",
    "comparator": "—",
    "outcome": "—",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "moderate",
  "evidence": [
    {
      "ref": "DOI:10.1371/journal.pone.0319099",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "moderate",
      "year": 2025,
      "amato_authored": false,
      "note": "Retrospective referral-centre study with validated instruments (SF-36, HADS, BPI, FSS) directly quantifying quality of life, depression, and anxiety in lipedema patients, showing high psychosocial burden dissociated from disease stage."
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000020",
    "source": "library",
    "ingested": "2026-05-31"
  },
  "created": "2026-05-31",
  "updated": "2026-05-31",
  "history": [
    {
      "date": "2026-05-31",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000020"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000020",
      "role": "supporting",
      "question": "How does lipedema affect quality of life, depression, and anxiety in affected patients?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000020.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000357.html"
}