{
  "id": "SCR-LIP-000395",
  "statement": "In a cross-sectional study of 1001 Spanish women with lipedema, thyroid disease was significantly more prevalent than in the general female population (OR=2.21; 95% CI: 1.8-2.6).",
  "statement_pt": "Em um estudo transversal com 1001 mulheres espanholas com lipedema, a doença da tireoide foi significativamente mais prevalente do que na população feminina geral (OR=2,21; IC 95%: 1,8-2,6).",
  "claim_type": "clinical_association",
  "context": {
    "population": "Spanish women with lipedema (n=1001)",
    "condition": "lipedema",
    "exposure": "lipedema diagnosis",
    "comparator": "general Spanish female population",
    "outcome": "prevalence of thyroid disease (OR=2.21)",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1177/02683555261435120",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2026,
      "amato_authored": false,
      "note": "The study directly compares thyroid disease prevalence in lipedema patients versus the general population, finding a significantly elevated odds ratio. However, the comparison is based on self-reported online questionnaire data versus surve",
      "title": "Prevalence of comorbidities associated with lipedema. A comparative study with the general population",
      "authors": "Vaquero-Ramiro et al.",
      "journal": "Phlebology: The Journal of Venous Disease"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000007",
    "source": "MED",
    "ingested": "2026-06-02"
  },
  "created": "2026-06-02",
  "updated": "2026-06-02",
  "history": [
    {
      "date": "2026-06-02",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000007"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000007",
      "role": "supporting",
      "question": "Is lipedema associated with thyroid disease?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000007.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000395.html"
}