{
  "id": "SCR-LIP-000396",
  "statement": "In a weighted National Inpatient Sample cohort of obese women, hypothyroidism was more prevalent among patients with lipedema than without (23.3% vs 19%, p<0.01), though this was an unadjusted comorbidity comparison rather than a multivariate-adjusted test.",
  "statement_pt": "Em uma coorte ponderada do National Inpatient Sample de mulheres obesas, o hipotireoidismo foi mais prevalente entre pacientes com lipedema do que sem (23,3% vs 19%, p<0,01), embora se trate de uma comparação de comorbidade não ajustada e não de um teste multivariado.",
  "claim_type": "clinical_association",
  "context": {
    "population": "obese women, lipedema vs non-lipedema inpatients",
    "condition": "lipedema",
    "exposure": "lipedema diagnosis",
    "comparator": "obese women without lipedema",
    "outcome": "prevalence of hypothyroidism",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "ref": "DOI:10.1177/1358863x231219006",
      "stance": "supporting",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2024,
      "amato_authored": false,
      "note": "The article reports a statistically significant higher crude prevalence of hypothyroidism in lipedema patients (23.3% vs 19%, p<0.01), which bears on the thyroid-lipedema association. However, this is an unadjusted prevalence comparison (no",
      "title": "Venous thromboembolic outcomes in patients with lymphedema and lipedema: An analysis from the National Inpatient Sample",
      "authors": "Khalid et al.",
      "journal": "Vascular Medicine"
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000007",
    "source": "library",
    "ingested": "2026-06-02"
  },
  "created": "2026-06-02",
  "updated": "2026-06-02",
  "history": [
    {
      "date": "2026-06-02",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000007"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000007",
      "role": "supporting",
      "question": "Is lipedema associated with thyroid disease?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000007.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000396.html"
}