{
  "id": "SCR-LIP-000398",
  "statement": "In 151 women, those with lipoedema (N=90) reported significantly higher LYMQOL-leg burden scores for symptoms (p=0.003), appearance (p=0.003) and mood (p=0.011), and worse LSIDS-L neurological, biobehavioral and resource scores than those with bilateral leg lymphoedema (N=61), indicating distinguishable HRQoL profiles despite similar symptoms.",
  "statement_pt": "Em 151 mulheres, aquelas com lipedema (N=90) relataram escores de carga LYMQOL-leg significativamente mais altos para sintomas (p=0,003), aparência (p=0,003) e humor (p=0,011), e piores escores LSIDS-L neurológicos, biocomportamentais e de recursos do que aquelas com linfedema bilateral de perna (N=61), indicando perfis de qualidade de vida distinguíveis apesar de sintomas semelhantes.",
  "claim_type": "clinical_association",
  "context": {
    "population": "women with lipoedema or bilateral leg lymphoedema at an Australian clinic",
    "condition": "lipedema",
    "exposure": "diagnosis of lipoedema",
    "comparator": "bilateral leg lymphoedema",
    "outcome": "HRQoL scores (LYMQOL-leg, LSIDS-L)",
    "scope": "auto-ingested from Layer 1 surveillance"
  },
  "knowledge_state": "emerging",
  "evidence_confidence": "low",
  "evidence": [
    {
      "title": "A retrospective cross-sectional study comparing health-related quality-of-life in females with lipoedema and bilateral leg lymphoedema.",
      "authors": "Stellmaker R, Thompson B, Mackie H, Paramanandam VS, Sherman KA, Koelmeyer L.",
      "ref": "DOI:10.1016/j.jpsychores.2026.112562",
      "stance": "refines",
      "study_design": "cross_sectional",
      "n": null,
      "risk_of_bias": "unknown",
      "grade": "low",
      "year": 2026,
      "amato_authored": false,
      "note": "The study found lipoedema and lymphoedema differ in specific HRQoL outcomes while sharing similar symptoms, supporting a qualified distinction between the conditions but only via patient-reported outcomes, not pathophysiology."
    }
  ],
  "relations": [],
  "gaps": "Auto-ingested single source; not yet human-reviewed.",
  "primary_amato_source": null,
  "curators": [],
  "provenance": {
    "auto": true,
    "engine": "anthropic/claude-opus-4.8",
    "question": "SQ-LIP-000001",
    "source": "MED",
    "ingested": "2026-06-07"
  },
  "created": "2026-06-07",
  "updated": "2026-06-07",
  "history": [
    {
      "date": "2026-06-07",
      "event": "created",
      "detail": "auto-ingested for SQ-LIP-000001"
    }
  ],
  "license": "CC-BY-4.0",
  "answers_questions": [
    {
      "id": "SQ-LIP-000001",
      "role": "refines",
      "question": "Is lipedema a distinct disease, separate from obesity and lymphedema?",
      "url": "https://scientificclaims.org/q/SQ-LIP-000001.html"
    }
  ],
  "url": "https://scientificclaims.org/c/SCR-LIP-000398.html"
}