SCR-LIP-000004 · Claim · machine-readable JSON →

Lipedema is a multifactorial disorder whose symptoms are closely linked to female hormonal transitions (puberty, pregnancy, menopause) and to chronic low-grade inflammation, on a polygenic predisposition.

Evidence over time

Evidence (2)

• DOI:10.1590/1677-5449.202301832 — supporting · consensus · n=113 · 2025 · risk of bias: moderate
  consensus: hormones trigger/exacerbate (4.46); inflammation contributes (4.25)
• Amato ACM, 2020 — supporting · expert opinion · 2020 · risk of bias: high

Context (PECO)

Answers these questions

• Do hormones and heredity influence the onset of lipedema? supporting

Gaps & caveats

Specific genes/mediators hypothesized rather than demonstrated in controlled studies.

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