SCR-LIP-000011 · Claim · machine-readable JSON →

Echogenic (hyperechoic) subcutaneous nodules in lipedema can be subclassified into at least four morphological variants (LDHC 3a-3d) whose distribution corresponds most strongly to the patient's most painful site.

Speculative diagnostic Evidence certainty: very low (GRADE)

Evidence over time

DOI:10.4236/jbise.2025.1810029 — supporting · case series · n=20 · 2025 · risk of bias: high
Foureaux et al.; 62 nodules; distribution tied to most painful site, not BMI/age

Populationlipedema patients classified LDHC 3, obesity excluded

Conditionlipedema

Exposureultrasound nodule morphology

Outcomenodule subclassification and pain correlation

Scopesingle-center, two radiologists

Small descriptive series; no histopathologic confirmation of subtypes.