SCR-LIP-000017 · Claim · machine-readable JSON →

Joint hypermobility (Hypermobility Spectrum Disorder) is a frequent comorbidity of lipedema, present in approximately 44% of adult patients in a cross-sectional cohort.

Emerging clinical association Evidence certainty: moderate (GRADE)

Evidence over time

DOI:10.3390/jcm14207195 — supporting · cross sectional · n=716 · 2025 · risk of bias: moderate
Fiengo & Sbarbati; 44% hypermobile (60% in childhood); n=670 lipedema

Populationwomen with lipedema (cross-sectional cohort)

Conditionlipedema

Exposurelipedema

Comparatorlymphedema patients / general population

Outcomejoint hypermobility (HSD)

Scopecomorbidity prevalence

Single-center cross-sectional; hypermobility cutoffs vary; not Amato-authored.