SCR-LIP-000035 · Claim · machine-readable JSON →

In women with lipedema, a low-carbohydrate high-fat (ketogenic) diet significantly reduces body weight, BMI and waist/hip circumferences over a mean of ~16 weeks.

Probable therapeutic Evidence certainty: moderate (GRADE)

Evidence over time

DOI:10.3390/nu16193276 — supporting · meta analysis · n=329 · 2024 · risk of bias: moderate
7 studies; MD weight 7.94, BMI 4.23, all p<0.0001; mean 15.85 weeks

Populationadult women with lipedema (PL/NO/IT cohorts)

Conditionlipedema

Exposurelow-carbohydrate high-fat / ketogenic diet

Comparatorpre-intervention baseline

Outcomebody weight, BMI, waist/hip circumference

Scopeanthropometric outcomes, pooled dietary studies

Few studies, modest N, no long-term follow-up; lipedema-specific fat vs general weight loss not isolated.