SCR-LIP-000036 · Claim · machine-readable JSON →

In women with lipedema, a ketogenic (low-carbohydrate, high-fat) diet produces a small but statistically significant reduction in pain sensitivity.

Emerging therapeutic Evidence certainty: low (GRADE)

Evidence over time

DOI:10.3390/nu16193276 — supporting · meta analysis · n=329 · 2024 · risk of bias: moderate
pooled pain MD 1.12 (0.44-1.79), p=0.001; fewer studies reported pain

Populationadult women with lipedema

Conditionlipedema

Exposureketogenic / LCHF diet

Comparatorpre-intervention baseline

Outcomepain sensitivity

Scopesymptomatic pain outcome

Heterogeneous self-report pain scales; causal separation from weight loss unproven.