SCR-LIP-000040 · Claim · machine-readable JSON →
There is no scientific evidence supporting gestrinone for lipedema: a PRISMA systematic review identified zero clinical trials, observational studies or case reports evaluating it, particularly as subcutaneous implants.
Claim at a glance
- Type
- therapeutic
- Knowledge state
- Evidence gap
- Evidence certainty
- high (GRADE)
- Evidence
- 1 source(s) · by Amato
- Answers
- 1 question(s)
- Dates
- 2026-05-30 → 2026-05-30
Structured evidence, machine-compiled — not a verdict.
Evidence over time
Evidence (1)
- Lack of Scientific Evidence for the Use of Gestrinone in the Treatment of Lipedema: A Systematic Review — Amato et al. (2025) ✓ verified — conflicting · systematic review · 2025 · risk of bias: low · reading confidence: high
“0 estudos elegíveis incluídos”
zero eligible studies; SBEM and Brazilian Lipedema Association oppose use
Context (PECO)
Answers these questions
Gaps & caveats
Absence of evidence (no studies) rather than demonstrated lack of effect; implant pharmacokinetics/safety never studied.
Change log
- 2026-05-30 — created