SCR-LIP-000041 · Claim · machine-readable JSON →

Lipedema-affected gluteofemoral adipose tissue shows elevated tissue histamine (~2.2-fold vs controls) in a preliminary metabolomic study.

Evidence over time

Evidence (1)

• DOI:10.7417/CT.2023.2496 — supporting · basic science · 2023 · risk of bias: high
  Bonetti et al.; preliminary metabolomics; needs replication

Context (PECO)

Answers these questions

• What is known about the inflammation and pain mechanism in lipedema tissue? supporting

Gaps & caveats

Preliminary finding needing independent replication with quantitative assays and matched controls.

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