SCR-LIP-000102 · Claim · machine-readable JSON →

Transcriptomic analysis of lipedema subcutaneous tissue identified differentially expressed genes linked to inflammation (MAFB, C1Q, C2, CD68, CD163, TREM2), adipogenesis (PRKG2, MEDAG, CSF1R, ERBB4), and pain transmission (SHTN1, SCN7A, SLC12A2), distinguishing lipedema from hypertrophied adipose tissue.

Claim at a glance

Structured evidence, machine-compiled — not a verdict.

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-sonnet-4.6 · 2026-05-31

Evidence over time

Transcriptomics of Subcutaneous Tissue of Lipedema Identified Differentially Expressed Genes Involved in Adipogenesis, Inflammation, and Pain — Streubel et al. (2024) ✓ verified — consistent · cross sectional · 2024 · reading confidence: high
“Inflamação/macrófagos M2 (upregulated): MAFB, C1Q, C2, CD68, CD209, CD163, CD84, BCAT1, TREM2, MRC1, F13A1, NTRK3 — perfil claramente polarizado para M2 (CD163+/CD209+/MRC1+) sustentando inflamação crônica de baixo grau”
Whole transcriptome analysis directly addresses inflammation and pain mechanisms in lipedema tissue by identifying specific differentially expressed genes; limited by small sample sizes per stage and lack of functional validation.

Populationwomen with lipedema subcutaneous adipose tissue

Conditionlipedema

Exposuretranscriptomic gene expression profiling

Comparatorhypertrophied adipose tissue controls

Outcomedifferentially expressed genes (inflammation, adipogenesis, pain)

Scopeauto-ingested from Layer 1 surveillance

Auto-ingested single source; not yet human-reviewed.