SCR-LIP-000102 · Claim · machine-readable JSON →
Transcriptomic analysis of lipedema subcutaneous tissue identified differentially expressed genes linked to inflammation (MAFB, C1Q, C2, CD68, CD163, TREM2), adipogenesis (PRKG2, MEDAG, CSF1R, ERBB4), and pain transmission (SHTN1, SCN7A, SLC12A2), distinguishing lipedema from hypertrophied adipose tissue.
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-sonnet-4.6 · 2026-05-31
Evidence over time
Evidence (1)
- Transcriptomics of Subcutaneous Tissue of Lipedema Identified Differentially Expressed Genes Involved in Adipogenesis, Inflammation, and Pain — Streubel et al. (2024) — supporting · cross sectional · 2024
Whole transcriptome analysis directly addresses inflammation and pain mechanisms in lipedema tissue by identifying specific differentially expressed genes; limited by small sample sizes per stage and lack of functional validation.
Context (PECO)
Answers these questions
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created