SCR-LIP-000110 · Claim · machine-readable JSON →
Lipedema is described as an estrogen-regulated polygenic disorder that manifests almost exclusively in women, with onset at hormonal transition phases (puberty, pregnancy, menopause), family aggregation in at least 16% of cases, and a pathological ERα/ERβ receptor pattern in white adipose tissue driving site-specific lipogenesis.
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-sonnet-4.6 · 2026-05-31
Evidence over time
Evidence (1)
- Lipödem – Grundlagen und aktuelle Thesen zum
Pathomechanismus — Wiedner et al. (2018) — supporting · review · 2018
This is a narrative/mechanistic literature review that explicitly addresses hormonal (estrogen-regulated) and hereditary (polygenic, familial aggregation) contributions to lipedema onset, directly supporting the question's affirmative direc
Context (PECO)
Answers these questions
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created