SCR-LIP-000114 · Claim · machine-readable JSON →

A modified Mediterranean-ketogenic diet (<30g carbohydrates/day, 70% lipids) over 10 weeks produced significant reductions in body weight, total fat mass, and leg fat mass (including by DXA) in women with lipedema, with lean mass preserved, and the combination with carboxytherapy additionally reduced pain and improved quality of life.

Claim at a glance

Structured evidence, machine-compiled — not a verdict.

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-sonnet-4.6 · 2026-05-31

Evidence over time

Modified Mediterranean-Ketogenic Diet and Carboxytherapy as Personalized Therapeutic Strategies in Lipedema: A Pilot Study — Di Renzo et al. (2023) ✓ verified — consistent · rct · 2023 · reading confidence: high
“A MMKD induziu perda significativa de peso e gordura corporal, incluindo nos membros inferiores (áreas consideradas resistentes à dietoterapia no lipedema). Os melhores resultados foram obtidos com a combinação KDCB”
This is a small pilot RCT (n=30, 26.7% dropout) with short follow-up (10 weeks) and no control group receiving standard diet, but it directly tests a ketogenic/low-carbohydrate diet in lipedema patients and reports significant improvements

Populationwomen with lipedema

Conditionlipedema

Exposuremodified Mediterranean-ketogenic diet (≤30g carbs/day, 70% lipids, 10 weeks) ± carboxytherapy

Comparatorpre-intervention baseline

Outcomebody weight, total/leg fat mass (DXA), lean mass, pain, quality of life

Scopeauto-ingested from Layer 1 surveillance

Auto-ingested single source; not yet human-reviewed.