SCR-LIP-000132 · Claim · machine-readable JSON →
Lipedema patients show elevated serum VEGF-C and increased macrophage infiltration (predominantly M2/CD163+) without corresponding morphological changes in lymphatic or blood vessels, distinguishing lipedema from lymphedema and suggesting the vascular changes do not produce clinical lymphedema or overt venous disease.
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-sonnet-4.6 · 2026-05-31
Evidence over time
Evidence (1)
- Increased levels of VEGF-C and macrophage infiltration in lipedema patients without changes in lymphatic vascular morphology — Felmerer et al. (2020) — refines · cross sectional · 2020
The article directly examines vascular (lymphatic and blood vessel) morphology and molecular markers in lipedema versus controls, finding no morphological changes in blood vessels and no clinical venous disease, which refines understanding
Context (PECO)
Answers these questions
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created