SCR-LIP-000148 · Claim · machine-readable JSON →
In a case series of five male lipedema patients, the one patient who underwent HLA typing was positive for both HLA-DQ2 and HLA-DQ8, and the authors cite prior data reporting HLA-DQ2 in 47.4% and HLA-DQ8 in 22.2% of women with lipedema; gluten-free dietary intervention was applied based on this positivity.
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- Lipedema in Men: A Retrospective Case Series of Five Patients From a Brazilian Referral Center — Amato et al. (2025) — supporting · case series · 2025
The article reports HLA-DQ2+/DQ8+ positivity in one male lipedema patient and references prior prevalence data linking these alleles to lipedema, plus use of gluten-free diet, directly bearing on the question. However, this is a single HLA-
Context (PECO)
Answers these questions
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created