SCR-LIP-000167 · Claim · machine-readable JSON →

In a cross-sectional study of 43 Czech women with lipedema, 50.9% had moderate-to-severe depressive symptoms (PHQ-9 >=10) and WHOQOL-BREF scores were low across domains (psychological 46.3, physical 50.8), with the psychological domain most affected; specific physical symptoms (shortness of breath, muscle stiffness, appetite problems, fatigue, numbness) were significantly associated with depression severity.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• Mental and physical health burden and quality of life in Czech women with lipedema — Kunzová et al. (2025) — supporting · cross sectional · 2025
  Cross-sectional observational study directly measuring depression (PHQ-9), quality of life (WHOQOL-BREF), and symptom associations in lipedema patients; small sample (n=43) and chi-square associations are unadjusted, limiting strength.

Context (PECO)

Answers these questions

• How does lipedema affect quality of life, depression, and anxiety in affected patients? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000020

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