SCR-LIP-000175 · Claim · machine-readable JSON →

In a cross-sectional study of 37 women with lipedema versus 36 with lymphedema, lipedema patients showed moderate depression (PHQ-9 mean 10.4) and impaired global quality of life (LYMQOL-Leg 5.47) comparable to lymphedema patients, while lymphedema patients had worse functional status and life satisfaction; in lipedema, longer disease duration correlated with PHQ-9 (r=-0.415, p=0.028) and BMI correlated with functional impairment.

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• The Comparative Evaluation of Depression, Life Satisfaction, and Quality of Life Between Female Patients with Lipedema and Lymphedema — Yaman et al. (2025) ✓ verified — consistent · cross sectional · 2025 · reading confidence: high
  “Funcionalidade (LEFS): SIGNIFICATIVAMENTE PIOR no linfedema — 0,4455 vs 0,6250 (p = 0,001)”
  Cross-sectional study directly measuring depression (PHQ-9), life satisfaction (LSI), and QoL (LYMQOL-Leg) in lipedema patients with validated instruments, reporting that lipedema is associated with moderate depression and reduced QoL, bear [grade capped moderate->low per curated Oxford N4]

Context (PECO)

Answers these questions

• Does lipedema progress to lymphedema and cause functional disability? refining
• How does lipedema affect quality of life, depression, and anxiety in affected patients? consistent
• Does lipedema cause functional disability and mobility limitation? refining
• How does lipedema affect health-related quality of life? consistent
• How does lipedema affect mental health (depression and anxiety)? consistent

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-06-02 — merged · absorbed duplicate SCR-LIP-000126
• 2026-05-31 — created · auto-ingested for SQ-LIP-000020

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