SCR-LIP-000176 · Claim · machine-readable JSON →
In a cross-sectional cohort of 40 lipedema patients, 87.5% showed severe/high depression risk (mean HAM-D 25.39) and 92.5% showed severe/high anxiety risk (mean HAM-A 23.45), with serum vitamin D inversely correlated with depression (adjusted r=-0.580, p<0.001) and anxiety (adjusted r=-0.489, p=0.002), and BMI positively correlated with both depression (r=0.560) and anxiety (r=0.511).
Claim at a glance
- Type
- clinical association
- Knowledge state
- Emerging
- Evidence certainty
- low (GRADE)
- Evidence
- 1 source(s)
- Answers
- 2 question(s)
- Dates
- 2026-05-31 → 2026-05-31
Structured evidence, machine-compiled — not a verdict.
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- The association between serum vitamin D and mood disorders in a cohort of lipedema patients — Al-Wardat et al. (2021) ✓ verified — consistent · cross sectional · 2021 · reading confidence: high
“87,5% das pacientes (n=35) apresentaram risco severo ou alto de depressão; escore médio HAM-D = 25,39”
The article directly documents high prevalence of depression and anxiety in lipedema patients and examines correlates (vitamin D, BMI, disease duration), bearing on how lipedema affects mood/QoL. Small single-cohort cross-sectional design w
Context (PECO)
Answers these questions
- How does lipedema affect quality of life, depression, and anxiety in affected patients? consistent
- How does lipedema affect mental health (depression and anxiety)? consistent
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000020