SCR-LIP-000176 · Claim · machine-readable JSON →

In a cross-sectional cohort of 40 lipedema patients, 87.5% showed severe/high depression risk (mean HAM-D 25.39) and 92.5% showed severe/high anxiety risk (mean HAM-A 23.45), with serum vitamin D inversely correlated with depression (adjusted r=-0.580, p<0.001) and anxiety (adjusted r=-0.489, p=0.002), and BMI positively correlated with both depression (r=0.560) and anxiety (r=0.511).

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• The association between serum vitamin D and mood disorders in a cohort of lipedema patients — Al-Wardat et al. (2021) — supporting · cross sectional · 2021
  The article directly documents high prevalence of depression and anxiety in lipedema patients and examines correlates (vitamin D, BMI, disease duration), bearing on how lipedema affects mood/QoL. Small single-cohort cross-sectional design w

Context (PECO)

Answers these questions

• How does lipedema affect quality of life, depression, and anxiety in affected patients? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000020

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