SCR-LIP-000194 · Claim · machine-readable JSON →

This systematic review describes lipedema diagnosis as primarily clinical and outlines a 3-stage clinical staging system (Stage I normal skin with small palpable nodules; Stage II irregular surface with liposclerosis; Stage III lobular deformation with peau d'orange) plus Schingale's 5-type classification (I hips/thighs, II to knees, III to ankles, IV arms+legs, V lipo-lymphedema), with key differential signs (negative Stemmer, foot dorsum sparing) and noncontrast CT reported at 95% sensitivity and 100% specificity.

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• Lipedema: an overview of its clinical manifestations, diagnosis and treatment of the disproportional fatty deposition syndrome – systematic review — Forner‐Cordero et al. (2012) ✓ verified — contextual · review · 2012 · reading confidence: high
  “Diagnóstico e tratamento devem ser realizados o mais cedo possível para prevenir complicações funcionais e cosméticas.”
  The systematic review directly compiles the clinical criteria, 3-stage staging and 5-type classification systems used to diagnose and grade lipedema, plus a differential diagnostic imaging accuracy figure, but it explicitly notes the absenc

Context (PECO)

Answers these questions

• Does lipedema progress to lymphedema and cause functional disability? contextual
• What clinical criteria and stage/type classification systems are used to diagnose and grade lipedema, and how reliable are they? contextual

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-06-02 — merged · absorbed duplicate SCR-LIP-000337
• 2026-05-31 — created · auto-ingested for SQ-LIP-000022
• 2026-06-12 — stance corrected · R-AI-14 audit: evidence stance supporting→context (adopted from independent verifier).

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