SCR-LIP-000198 · Claim · machine-readable JSON →

In 50 lipedema patients versus 50 controls, ICG lymphography and lymphoscintigraphy revealed slower superficial lymph flow (ICG reached upper calf in 8% vs 56%, p<0.0001), more numerous and dilated/tortuous lymphatic vessels, higher fluorescence intensity, higher skin water concentration in the feet (p=0.000189), and increased subcutaneous tissue stiffness, supporting their utility in diagnosing lipedema.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• Lower Limb Lipedema–Superficial Lymph Flow, Skin Water Concentration, Skin and Subcutaneous Tissue Elasticity — Zaleska et al. (2023) — supporting · cross sectional · 2023
  Controlled cross-sectional study using lymphoscintigraphy, ICG lymphography, and tissue measurements to differentiate lipedema limbs from normal controls, directly addressing whether imaging/measurement modalities can characterize lipedema,

Context (PECO)

Answers these questions

• Can MRI, lymphoscintigraphy, or DXA differentiate lipedema from lymphedema and other fat distributions? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000023

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