SCR-LIP-000202 · Claim · machine-readable JSON →

On non-contrast MR lymphography of 44 lower extremities, pure lipedema showed homogeneous subcutaneous fat without epifascial fluid (0%) while lipolymphedema showed epifascial fluid collections (100%, p<.001) and dilated peripheral lymphatics (90.9% vs 18.2%, p=.001), with no honeycomb pattern and normal iliac lymphatic trunks in both groups.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• Non-contrast MR Lymphography of lipedema of the lower extremities — Cellina et al. (2020) — supporting · case series · 2020
  Retrospective imaging study (n=22 patients) directly comparing MR lymphography findings between lipedema and lipolymphedema, identifying distinguishing features for differential diagnosis; small sample limits confidence.

Context (PECO)

Answers these questions

• Can MRI, lymphoscintigraphy, or DXA differentiate lipedema from lymphedema and other fat distributions? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000023

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