SCR-LIP-000218 · Claim · machine-readable JSON →
A systematic review of lipedema pathology reported that, despite growing histological and molecular research, the aetiology remains largely uncertain; it noted differential gene expression in lipedema adipose-derived stem cells (3429 genes, including cell-cycle genes Bub1, CDC20, BIRC5 per Ishaq) but did not identify specific inherited variants or defined inheritance patterns.
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- Auf der Suche nach der Evidenz: Eine systematische
Übersichtsarbeit zur Pathologie des Lipödems — Funke et al. (2023) — context · review · 2023
The review addresses molecular/pathogenesis findings including differential gene expression but does not identify specific genetic variants or inheritance patterns; it explicitly states aetiology remains uncertain. It provides background co
Context (PECO)
Answers these questions
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000025