SCR-LIP-000220 · Claim · machine-readable JSON →
This narrative review reports genetic evidence (305 candidate genes via next-generation sequencing in 162 patients; 18 GWAS risk loci including VEGFA and GRB14-COBLL1 validated in UK Biobank; monogenic AKR1C1 and PIT1 mutations affecting progesterone and growth-hormone/prolactin pathways) supporting both hereditary and hormonal influences on lipedema onset.
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- Lipedema: Progress, Challenges, and the Road Ahead — Cifarelli (2025) — supporting · review · 2025
The review synthesizes genetic studies (GWAS, sequencing) showing heritable loci and monogenic mutations in hormone-related genes (AKR1C1 affecting progesterone, PIT1 affecting GH/prolactin/TSH), directly supporting both hereditary and horm
Context (PECO)
Answers these questions
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000012