SCR-LIP-000223 · Claim · machine-readable JSON →
This multidisciplinary review reports that lipedema shows familial history in 30-89% of cases with polygenic GWAS findings (loci in CPE, ZNF25, ZNF33A linked to estrogen biology, plus VEGFA and GRB14-COBLL1, and an AKR1C1 missense variant) and that onset or worsening clusters at hormonal transitions—puberty (15.7-67.3%), pregnancy/lactation (9.5-63.1%), and menopause (1.9-21%)—with estradiol altering ERα/ERβ and PPAR-γ2 expression in lipedema-derived adipose stem cells.
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- Unraveling lipedema: comprehensive insights and the path to future discoveries — Faria et al. (2025) — supporting · review · 2025
The review directly synthesizes genetic (familial history, GWAS, AKR1C1) and hormonal (puberty/pregnancy/menopause onset, estradiol effects on ASCs) evidence bearing on the onset of lipedema, supporting the affirmative direction; confidence
Context (PECO)
Answers these questions
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000012