SCR-LIP-000228 · Claim · machine-readable JSON →
A systematic review of genetic data proposes that primary lipedema follows an autosomal dominant inheritance pattern with incomplete penetrance and sex-limited expression (predominantly affecting women), with positive family history self-reported in up to 64% of women, and identifies syndromic forms linked to hormonal regulators including POU1F1A (Pit-1 regulating GH, PRL, TSH) and NSD1 (potentiating androgen receptor transactivation and estrogen-mediated tissue expansion).
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- DOI:10.26355/eurrev_201907_18292 — supporting · review · 2019
The systematic review directly addresses both heredity (proposing autosomal dominant inheritance with sex-limitation and high family-history rates) and hormonal influence (syndromic genes regulating GH/PRL/TSH and androgen/estrogen-mediated
Context (PECO)
Answers these questions
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000012