SCR-LIP-000230 · Claim · machine-readable JSON →
This review reports that lipedema develops or worsens during hormonal-change windows (puberty, pregnancy, menopause, oral contraceptives), with ~20% of cases identified at menopause and ~67% of patients reporting symptom exacerbation at its onset, and proposes an estrogen-receptor imbalance (decreased ERalpha/increased ERbeta) in affected adipose tissue as a central mechanism.
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- Lipedema: From Women’s Hormonal Changes to Nutritional Intervention — Tomada (2025) — supporting · review · 2025
Narrative review summarizing hormonal etiopathogenesis of lipedema, including estrogen, estrogen receptor ratios, and reproductive-life hormonal triggers; directly addresses the hormonal influence on onset, though heredity is not strongly d
Context (PECO)
Answers these questions
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000012