SCR-LIP-000233 · Claim · machine-readable JSON →

In a series of 67 probands, 14.9% had a first-degree relative with confirmed lipedema and X-chromosome linkage analysis in the largest family (Li05) returned lod scores below -2, excluding X-linked dominant inheritance and favoring autosomal dominant inheritance with sex limitation.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• Lipedema: An inherited condition — Child et al. (2010) — supporting · case series · 2010
  The article directly addresses inheritance patterns in lipedema, constructing pedigrees and performing X-chromosome linkage analysis, proposing autosomal dominant inheritance with sex limitation as the most likely pattern.

Context (PECO)

Answers these questions

• What specific genetic variants or inheritance patterns have been identified in lipedema? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000025

← All claims