SCR-LIP-000253 · Claim · machine-readable JSON →
In an 8-week RCT of 13 females with obesity and lipedema, a 1,200 kcal/day low-carbohydrate diet (75 g/day carbohydrates) produced significant reductions in calf subcutaneous adipose tissue area, calf circumference, and pain not seen in the isoenergetic low-fat control group, while both diets reduced body weight, fat mass, and muscle area.
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- DOI:10.3389/fnut.2024.1484612 — supporting · rct · 2024
Randomized controlled trial directly testing a low-carbohydrate diet in lipedema patients, showing benefits on SAT and pain; however, very small sample (n=13, only 5 in LCD group) limits confidence.
Context (PECO)
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Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000014