SCR-LIP-000256 · Claim · machine-readable JSON →

In BMI-matched comparisons, lipedema tissue showed no morphological lymphatic vessel changes (vessel number 2.28 vs 2.62/field, ns) unlike lymphedema, with elevated serum VEGF-C (4364 vs 3275 pg/mL, p=0.02) and increased M2 macrophage infiltration (CD68+ 21.2 vs 13 cells/field, p=0.009; CD163 up 3.4x), contrasting with the CD4+ T-cell-dominant inflammation of lymphedema.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• DOI:10.1038/s41598-020-67987-3 — supporting · cross sectional · 2020
  Cross-sectional histological/molecular comparison of 11 lipedema vs 10 BMI-matched controls showing distinct lymphatic and inflammatory phenotype differentiating lipedema from lymphedema, supporting it as a distinct entity.

Context (PECO)

Answers these questions

• Is lipedema a distinct disease, separate from obesity and lymphedema? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000001

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