SCR-LIP-000257 · Claim · machine-readable JSON →
This review describes lipedema as a distinct fat disorder differentiated from obesity by adipose tissue resistant to diet/exercise and ineffective bariatric surgery, and from lymphedema by absence of foot involvement (cuff sign, negative Stemmer sign in early stages) and helical/corkscrew-shaped lymphatic vessels.
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- DOI:10.1097/psn.0000000000000245 — supporting · review · 2018
Narrative clinical review compiling literature on lipedema pathophysiology, diagnostic differentiation from obesity and lymphedema, and treatment; explicitly characterizes lipedema as a distinct clinical entity with specific distinguishing
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Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000001