SCR-LIP-000258 · Claim · machine-readable JSON →

In a retrospective review of 250 lower-extremity lymphedema cases, 9 female patients showed bilateral symmetrical swelling sparing the feet, absence of Stemmer sign and other lymphedema skin changes, and consistent fat pads anterior to the lateral malleoli, identifying lipedema as a clinical entity distinct from lymphedema requiring different treatment.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• DOI:10.1097/00006534-199411000-00014 — supporting · case series · 1994
  Case series of 9 patients distinguishing lipedema from lymphedema by specific clinical findings (bilateral symmetric edema sparing feet, no Stemmer sign, malleolar fat pads), directly supporting lipedema as a distinct entity; small sample l

Context (PECO)

Answers these questions

• Is lipedema a distinct disease, separate from obesity and lymphedema? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000001

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