SCR-LIP-000265 · Claim · machine-readable JSON →

In a comparative lymphoscintigraphy study (15 women with lipedema vs 15 with primary lymphedema), inguinal lymph nodes were absent in 14/15 lymphedema cases but only 1/15 lipedema cases (p<0.001) and colloid half-life was longer in lymphedema (230±92 vs 121±36 min, p<0.01), and the Stemmer sign is positive in lymphedema but negative in lipedema, with the review describing lymphedema and lipedema as distinct entities and lipedema's fat distinct from obesity (weight loss reduces truncal but not limb fat).

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• DOI:10.1024/0301-1526.37.1.39 — supporting · review · 2008
  Comparative review explicitly distinguishing lipedema from lymphedema via clinical sign (Stemmer) and lymphoscintigraphy data, and from obesity via fat distribution response to weight loss; directly addresses the question's affirmative dire

Context (PECO)

Answers these questions

• Is lipedema a distinct disease, separate from obesity and lymphedema? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000001

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