SCR-LIP-000289 · Claim · machine-readable JSON →

In 50 lipedema patients versus 50 controls, ICG lymphography showed slower superficial lymph flow (ICG reached upper calf in 8% vs 56%, p<0.0001), more visualized lymphatic vessels, higher fluorescence intensity at all limb levels, increased skin water concentration in the feet (p=0.000189), and stiffer subcutaneous tissue, demonstrating these multimodal measures can help diagnose lipedema though precise diagnostic criteria still require further study.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• DOI:10.1089/lrb.2022.0010 — supporting · cross sectional · 2023
  The study evaluates measurable physiological and tissue parameters (ICG lymphography, skin water, elasticity) for their utility in diagnosing lipedema, directly addressing whether diagnostic/screening tools can identify the condition, with

Context (PECO)

Answers these questions

• Is lipedema underdiagnosed, and can screening tools help identify it? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000004

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