SCR-LIP-000305 · Claim · machine-readable JSON →
In subcutaneous adipose tissue of 11 lipedema patients versus BMI-matched controls, MIF-1 mRNA (fold-change 1.256; p=0.0485) and CD74 mRNA (1.514; p=0.0097) were elevated, with CD74 also overexpressed at the cellular level by immunohistochemistry (7.73 vs 5.18; p=0.0026), while MIF-2 was unchanged and CXCR2 was higher in controls, implicating the MIF-1/CD74 axis in inflammatory macrophage recruitment and polarization in lipedema independent of BMI.
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
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Evidence (1)
- DOI:10.3390/metabo13101105 — supporting · basic science · 2023
Small descriptive cross-sectional tissue study (n=11 per group) reporting elevated MIF-1/CD74 expression and macrophage-related inflammatory mechanisms in lipedema adipose tissue, directly addressing inflammation mechanisms; no functional v
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Auto-ingested single source; not yet human-reviewed.
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- 2026-05-31 — created · auto-ingested for SQ-LIP-000011