SCR-LIP-000306 · Claim · machine-readable JSON →
In lipedema adipose tissue, immunohistochemistry showed increased CD45+ leukocytes (45.7 vs 28 cells/field, P<0.001) and CD68+ macrophages (19.5 vs 12.3, P=0.01) without increased CD3+ T cells, while systemic adipokines IL-6, IL-18, lipocalin-2 and leptin did not differ from controls.
Claim at a glance
- Type
- clinical association
- Knowledge state
- Emerging
- Evidence certainty
- low (GRADE)
- Evidence
- 1 source(s)
- Answers
- 1 question(s)
- Dates
- 2026-05-31 → 2026-05-31
Structured evidence, machine-compiled — not a verdict.
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- Adipose Tissue Hypertrophy, An Aberrant Biochemical Profile and Distinct Gene Expression in Lipedema — Felmerer et al. (2020) ✓ verified — refining · case series · 2020 · reading confidence: high
The article directly characterizes tissue-level inflammation in lipedema, reporting a predominantly macrophage-based infiltrate without a T-cell component and no systemic adipokine elevation, which informs the inflammation mechanism but doe
Context (PECO)
Answers these questions
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000011