SCR-LIP-000306 · Claim · machine-readable JSON →

In lipedema adipose tissue, immunohistochemistry showed increased CD45+ leukocytes (45.7 vs 28 cells/field, P<0.001) and CD68+ macrophages (19.5 vs 12.3, P=0.01) without increased CD3+ T cells, while systemic adipokines IL-6, IL-18, lipocalin-2 and leptin did not differ from controls.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• DOI:10.1016/j.jss.2020.03.055 — refines · case series · 2020
  The article directly characterizes tissue-level inflammation in lipedema, reporting a predominantly macrophage-based infiltrate without a T-cell component and no systemic adipokine elevation, which informs the inflammation mechanism but doe

Context (PECO)

Answers these questions

• What is known about the inflammation and pain mechanism in lipedema tissue? refines

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000011

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