SCR-LIP-000307 · Claim · machine-readable JSON →
In anatomically-matched biopsies from 11 lipedema versus 10 BMI-matched healthy patients, lipedema tissue showed roughly doubled CD45+ leukocyte infiltration (40.7 vs 20 cells/field, p<0.0001) and increased CD68+ macrophages (21.2 vs 13 cells/field, p=0.009) with predominantly M2 polarization (CD163 increased 3.4x), alongside elevated serum VEGF-C (4364 vs 3275 pg/mL, p=0.02), reduced tissue Tie2 (5.7x lower), VEGF-A and VEGF-D, but no morphological lymphatic changes or systemic inflammation markers.
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- DOI:10.1038/s41598-020-67987-3 — supporting · cross sectional · 2020
The article directly characterizes inflammatory mechanisms in lipedema tissue, demonstrating macrophage infiltration with M2 polarization and a VEGF-C/lymphatic-axis profile, which bears on the inflammation mechanism component of the questi
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Auto-ingested single source; not yet human-reviewed.
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- 2026-05-31 — created · auto-ingested for SQ-LIP-000011