SCR-LIP-000309 · Claim · machine-readable JSON →
In thigh skin and fat biopsies, lipedema (non-obese and obese) showed significantly increased CD68+ macrophages versus BMI-matched controls (p<0.005 and p<0.05) and crown-like structures absent in all controls (12.5-14% of lipedema cases), while CD3+ T-lymphocytes and CD117+ mast cells did not differ; dermal vessel number correlated with macrophage count (r²=0.45, p=0.05), and focal angiogenesis with fibrosis occurred in 30% of non-obese lipedema cases but no controls.
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- DOI:10.1155/2019/8747461 — supporting · cross sectional · 2019
Histological cross-sectional study directly examining inflammatory cells, vascular changes, and adipocyte structure in lipedema tissue stratified by BMI, providing evidence on inflammation mechanisms (macrophage infiltration, crown-like str
Context (PECO)
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Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000011