SCR-LIP-000312 · Claim · machine-readable JSON →
This systematic review reports that lipedema adipose tissue and ASCs show elevated IL-8 in ASC supernatants, elevated serum IL-28A, IL-29 and IL-11, increased oxidative stress markers (malondialdehyde and protein carbonyls), and VE-cadherin downregulation suggesting vascular barrier dysfunction, indicating inflammatory and stress-related mechanisms.
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- DOI:10.3390/jpm13010098 — supporting · review · 2023
The review synthesizes molecular/cellular findings including inflammatory cytokines (IL-8, IL-28A, IL-29, IL-11) and oxidative stress markers in lipedema tissue, directly bearing on inflammation mechanisms, though it notes methodological li
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Auto-ingested single source; not yet human-reviewed.
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- 2026-05-31 — created · auto-ingested for SQ-LIP-000011