SCR-LIP-000341 · Claim · machine-readable JSON →

In a Swiss referral cohort of 381 lipedema patients, chronic vascular disease was the dominant comorbidity affecting 86.2% (predominantly chronic venous disease rather than atherosclerosis), and comorbidity burden increased with stage on univariate analysis (OR 1.59, 95% CI 1.39–1.81) but lost independent significance after adjusting for age and BMI in multivariate regression.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• DOI:10.1371/journal.pone.0319099 — supporting · cohort · 2025
  Large retrospective cohort directly reports chronic venous disease as the dominant comorbidity (86.2%) in lipedema patients, bearing on the question of venous disease association; however the comorbidity-stage link lost independence after a

Context (PECO)

Answers these questions

• How does lipedema relate to varicose veins and venous disease? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000018

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