SCR-LIP-000355 · Claim · machine-readable JSON →
In 511 lipedema patients, PHQ-9 averaged 10.84±6.39 with 54% at risk of moderate-to-severe depression, WHOQOL-BREF global score averaged 60.5±16.02 (lowest in physical 54.54 and psychological 51.91 domains), and quality-of-life impairment correlated with disease stage (r=0.55, p<0.001) and inversely with depression score (r=-0.775, p<0.0001).
Claim at a glance
- Type
- clinical association
- Knowledge state
- Emerging
- Evidence certainty
- low (GRADE)
- Evidence
- 2 source(s)
- Answers
- 3 question(s)
- Dates
- 2026-05-31 → 2026-06-12
Structured evidence, machine-compiled — not a verdict.
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (2)
- Characteristics and Patient Reported Outcome Measures in Lipedema Patients—Establishing a Baseline for Treatment Evaluation in a High-Volume Center — Hamatschek et al. (2022) ✓ verified — consistent · cross sectional · 2022 · reading confidence: high
Large cross-sectional study using validated PROMs (WHOQOL-BREF, PHQ-9) directly quantifying quality of life and depression in lipedema patients, with stage-dependent correlations; directly addresses the question's affirmative direction. - Understanding the Vicious Circle of Pain, Physical Activity, and Mental Health in Lipedema Patients – a Response Surface Analysis — Aitzetmüller-Klietz et al. (2023) ✓ verified — consistent · cross sectional · 2023 · reading confidence: high
Cross-sectional self-report study quantifying depression (PHQ-9) and quality-of-life dimensions (WHOQOL-BREF) in lipedema patients, with response surface analysis showing pain and physical inactivity drive worse mental health and QoL, direc
Context (PECO)
Answers these questions
- How does lipedema affect quality of life, depression, and anxiety in affected patients? consistent
- How does lipedema affect health-related quality of life? consistent
- How does lipedema affect mental health (depression and anxiety)? consistent
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000020
- 2026-05-31 — evidence added · corroborated by DOI:10.21203/rs.3.rs-2705753/v1
- 2026-06-12 — disputed evidence reviewed · Human review: synthesis — this source supports the claim's direction; the specific variant(s)/figure(s) it lacks are present in a sibling source (per-claim integrity clean). Accepted.