SCR-LIP-000355 · Claim · machine-readable JSON →
In 511 lipedema patients, PHQ-9 averaged 10.84±6.39 with 54% at risk of moderate-to-severe depression, WHOQOL-BREF global score averaged 60.5±16.02 (lowest in physical 54.54 and psychological 51.91 domains), and quality-of-life impairment correlated with disease stage (r=0.55, p<0.001) and inversely with depression score (r=-0.775, p<0.0001).
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (2)
- DOI:10.3390/jcm11102836 — supporting · cross sectional · 2022
Large cross-sectional study using validated PROMs (WHOQOL-BREF, PHQ-9) directly quantifying quality of life and depression in lipedema patients, with stage-dependent correlations; directly addresses the question's affirmative direction. - DOI:10.21203/rs.3.rs-2705753/v1 — supporting · cross sectional · 2023
Cross-sectional self-report study quantifying depression (PHQ-9) and quality-of-life dimensions (WHOQOL-BREF) in lipedema patients, with response surface analysis showing pain and physical inactivity drive worse mental health and QoL, direc
Context (PECO)
Answers these questions
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000020
- 2026-05-31 — evidence added · corroborated by DOI:10.21203/rs.3.rs-2705753/v1