SCR-LIP-000366 · Claim · machine-readable JSON →

In a Swiss cohort of 381 lipedema patients classified by type (I-V) and stage (1-4), advanced stage correlated with age and BMI, but a Stemmer sign was positive in only 4.0% and validated questionnaire scores (HADS, BPI, FSS, SF-36) did not differ significantly between stages (p>0.5), revealing a dissociation between morphological stage and symptom burden.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• DOI:10.1371/journal.pone.0319099 — context · cohort · 2025
  The article applies the standard type (I-V) and stage (1-4) classification systems and reports their clinical correlates, including a dissociation between morphological stage and symptoms and the diagnostic relevance of negative Stemmer sig

Context (PECO)

Answers these questions

• What clinical criteria and stage/type classification systems are used to diagnose and grade lipedema, and how reliable are they? context

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000022

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