SCR-LIP-000372 · Claim · machine-readable JSON →

In a cross-sectional study of 115 Saudi patients with lower-limb edema, clinical diagnosis of lipedema used a structured assessment including signs (cuff/collar sign, Stemmer sign, telangiectasias, non-pitting orthostatic edema), severity grading 1-4 and anatomical type classification 1-5; clinical criteria confirmed lipedema in 71% (82/115), grade 2 was most common (31%), type 3 (hip-to-ankle) predominant (47%), and the cuff/collar sign correlated with advanced stages (80% of those with the sign were ≥grade 2).

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• DOI:10.1097/gox.0000000000006173 — supporting · cross sectional · 2024
  The study explicitly applies clinical diagnostic criteria, a 1-4 grading system, and a 1-5 type classification, reporting their distribution and a correlation between the collar sign and disease stage, directly bearing on the question of cl

Context (PECO)

Answers these questions

• What clinical criteria and stage/type classification systems are used to diagnose and grade lipedema, and how reliable are they? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000022

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