SCR-LIP-000373 · Claim · machine-readable JSON →

The German S1 guideline defines lipedema diagnostic criteria (onset at puberty/pregnancy/menopause, disproportional adipose proliferation sparing hands and feet, periarticular cuffing, palpation hypersensitivity, increasing edema, negative Stemmer sign) and classifies it by three morphological stages and by anatomical location, with differential criteria distinguishing it from lipohypertrophy, obesity, and lymphedema.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• DOI:10.1111/ddg.13036 — supporting · review · 2017
  This consensus-based guideline directly specifies the clinical diagnostic criteria and stage/location classification systems for lipedema, but it is an S1 (lowest evidence-level) guideline based on expert consensus and notes diagnostic unce

Context (PECO)

Answers these questions

• What clinical criteria and stage/type classification systems are used to diagnose and grade lipedema, and how reliable are they? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000022

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