SCR-LIP-000380 · Claim · machine-readable JSON →

In 40 women with clinically diagnosed lipedema, ICG lymphography classified 85% as MDACC Stage 0 (normal lymphatics) and showed a distinguishable pattern (linear vessels without dermal backflow) versus the extensive dermal backflow of bilateral lymphedema, with only 5% having lymphedema and a negative Stemmer sign consistently corresponding to normal lymphatic morphology.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• DOI:10.1111/cob.12588 — supporting · cross sectional · 2023
  Cross-sectional study directly testing whether ICG lymphography imaging can differentiate lipedema from bilateral lower limb lymphedema; demonstrates distinct imaging patterns supporting the affirmative.

Context (PECO)

Answers these questions

• Can MRI, lymphoscintigraphy, or DXA differentiate lipedema from lymphedema and other fat distributions? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000023

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