SCR-LIP-000380 · Claim · machine-readable JSON →
In 40 women with clinically diagnosed lipedema, ICG lymphography classified 85% as MDACC Stage 0 (normal lymphatics) and showed a distinguishable pattern (linear vessels without dermal backflow) versus the extensive dermal backflow of bilateral lymphedema, with only 5% having lymphedema and a negative Stemmer sign consistently corresponding to normal lymphatic morphology.
Claim at a glance
- Type
- clinical association
- Knowledge state
- Emerging
- Evidence certainty
- low (GRADE)
- Evidence
- 1 source(s)
- Answers
- 2 question(s)
- Dates
- 2026-05-31 → 2026-05-31
Structured evidence, machine-compiled — not a verdict.
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- Differentiation of lipoedema from bilateral lower limb lymphoedema by imaging assessment of indocyanine green lymphography — Mackie et al. (2023) ✓ verified — consistent · cross sectional · 2023 · reading confidence: high
Cross-sectional study directly testing whether ICG lymphography imaging can differentiate lipedema from bilateral lower limb lymphedema; demonstrates distinct imaging patterns supporting the affirmative.
Context (PECO)
Answers these questions
- Can MRI, lymphoscintigraphy, or DXA differentiate lipedema from lymphedema and other fat distributions? consistent
- Can lymphoscintigraphy differentiate lipedema from lymphedema? consistent
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000023