SCR-LIP-000393 · Claim · machine-readable JSON →
A PCR adipogenesis array of 84 genes in lipedema adipose tissue versus matched controls found 5 differentially expressed genes (upregulated CCND1 2.16x; downregulated CEBPD -2.7x, CFD -1.88x, NCOR2 -1.81x, KLF4 -3.57x), reflecting altered gene expression rather than identifying germline genetic variants or inheritance patterns.
Claim at a glance
- Type
- clinical association
- Knowledge state
- Emerging
- Evidence certainty
- low (GRADE)
- Evidence
- 1 source(s)
- Answers
- 1 question(s)
- Dates
- 2026-05-31 → 2026-05-31
Structured evidence, machine-compiled — not a verdict.
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- Adipose Tissue Hypertrophy, An Aberrant Biochemical Profile and Distinct Gene Expression in Lipedema — Felmerer et al. (2020) ✓ verified — contextual · cross sectional · 2020 · reading confidence: high
The article reports differential gene EXPRESSION (transcript-level) in lipedema adipose tissue, not specific genetic variants or inheritance patterns. It provides molecular context relevant to lipedema genetics but does not directly address
Context (PECO)
Answers these questions
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000025