SCR-LIP-000002 · Claim · machine-readable JSON →
Clinical signs that help diagnose lipedema and distinguish it from lymphedema include a usually negative Kaposi-Stemmer sign, the cuff sign with foot sparing, fat painful on palpation, easy bruising, and minimal pitting edema (Stemmer becomes positive only when secondary lymphedema/lipolymphedema develops).
Claim at a glance
- Type
- diagnostic
- Knowledge state
- Probable
- Evidence certainty
- very low (GRADE)
- Evidence
- 2 source(s) · by Amato
- Answers
- 1 question(s)
- Dates
- 2026-05-30 → 2026-05-30
Structured evidence, machine-compiled — not a verdict.
Evidence over time
Evidence (2)
- Brazilian Consensus Statement on Lipedema using the Delphi methodology — Amato et al. (2025) ✓ verified — consistent · consensus · n=113 · 2025 · risk of bias: moderate · reading confidence: high
“distribuição desproporcional de TAS e ausência de relação causal com obesidade — nenhuma das afirmações fisiopatológicas recebeu nível de evidência A”
consensus on Stemmer, pain, bruising, pitting - Amato ACM, 2019 unverified — consistent · case report · n=1 · 2019 · risk of bias: high
comparative table
Context (PECO)
Answers these questions
Gaps & caveats
Signs lack validated sensitivity/specificity; diagnosis remains clinical and operator-dependent.
Change log
- 2026-05-30 — created